clomid babies have high risk of m/c??
20 Replies
isra - August 7

do u know anything about the clomid babies? have they high risk of m/c than normal pregnancy?anybody out there? thx


D. - August 7

There's a higher risk, not a high risk. There's a big difference. Far more clomid pregnancies end happily than sadly!


jenn - August 7

well not everyone evn gets pregnant on clomid. i actually think it sucks!


hayley - August 7

well that is your coment clomid works gud for sum people i have been trying to get pregant for 3 years i have just finshed clomid and it did not work for me but it does work for other people just not for all of us i wish all of u the best of luck


jenn - August 7

yes that is my comment, i truly feel after 1 year on it it wasnt worth the side affects as i didnt get pregnant. it is good for some i have a friend pregnant on one cycle and first time ever ttc.


Lena - August 8

Clomid does not effect ovum quality. There is absolutely no increase in the number of m/c in women that used clomid to produce follicles.


Dak - August 8

From my experience, I think Clomid has does not have a higher lisk of m/c. This is because there are some people who have up to 3 children that were conceived using Clomid. You can have a m/c but it doesnt mean you will miscarry again. Usually you will not. You will sometimes m/c after Clomid if the hormone levels drop while still pregnant and if there is no progestorone suppliments taken. My story; I fallen pregnant in March 2005 after 2 years of trying. This was first cycle on Clomid 50mg. Unfortunately I lost it on June 3 05. It has now been 9 weeks. I have a friend who has a boy. She fallen preg with 1st cycle of Clomid but lost it at 2 months. She carried the 2nd preg to term. So it depends on one body. If you conceive after takin gClomid make sure you take progestorone suppliments. I think I lost mine because my levels were very low and I was not given the suppiments because my DR who comes from Philipines was on holiday. Good luk to everyone


D. - August 8

There are two reasons why Clomid involves a higher risk of miscarriage: 1) The clomid has a detrimental effect on the uterine lining. It thins it. Because of the thin lining, which isn't a healthy environment for the embryo, you may miscarry. 2)
Clomid may allow you to relase multiple eggs.
Not all of these eggs are optimal quality all of the time.
Should the one of these lower quality eggs get fertilized, you're more likely to miscarry.


D - August 8

Here's an easy read on it


Lena - August 8

D, you are so right about the indirect effects of clomid. A thin lining can be attributed directly to clomid, but a triple lining can be measured several days before ovulation, which would give the patient the option of moving forward toward conception. Regarding subquality eggs, it hasn't been proven the clomid can be attributed to the ovulation of subquality eggs. There has been no research to support this. Do women who take clomid experience higher EED or reabsorption? Yes, but most woman on clomid already suffer from ovulatory problems with eggs that are subfertile. Generally speaking, in non clomid woman subquality eggs aren't ovulated or if they do and become fertilized, they don't reach the embryonic stage. With regards to 2nd or 3rd term m/c, there would be no statistical difference between clomid babies and nonclomid babies.


D. - August 8

It's not that the Clomid CAUSES subquality eggs. It means simply that we may already have subquality eggs in the till, so to speak. When the eggs mature, Clomid makes no differentiation between an egg that will provide a genetically perfect embryo and one that will not. So, along with the good may come the bad. I'm 39. More than a few of my eggs are less than fresh. When on Clomid, I may release, for example, 4 eggs. Of those, at least one may be not so great. That one may be fertilized while the other three not. Even if all 4 fertilized, the chance that that one bad egg will miscarry is greater. If I had released only one egg and it had been one of the others, I may not be facing as high a risk of miscarriage as I will having 4 out there and one bad. The chances that I have more than 1 out 4 not so great eggs is far more likely because of my age and history of infertiility. So, again, my chances are greater to suffer a miscarriage, regardless as to my situation, because I took the clomid, simply because the numbers are greater. Does that make more sense?


Lena - August 8

I understand the point you are making and your logic behind it, but keep in mind that clomid is a follicle stimulator not an ovulator. It may cause an ovum that normally would be passed by in a cycle to develop a follicle, but that doesn't necessarily mean that the follicle would ovulate, nor does it mean that clomid caused the ovum to be subquality. So even though clomid may cause a subquality egg to mature, and say that egg fertilized and then m/c, it was already a subquality egg. From a scientific standpoint the m/c can't be attributed to the clomid because the egg quality was already poor.


D. - August 8

We'll have to agree to disagree on that point, I'm afraid. :)


Jess - August 9

Can anyone out there tell me how much it costs for a cycle of clomid.?My husband and I are considering some fertility treatments because I have irregular periods.


Jill - August 9

Something no one has yet pointed out; the higher rate of miscarriage may be linked to the cause of the woman going on Clomid. Not having anything to do with the Clomid itself, but (for example) endometriosis. In that situation, the woman may not otherwise have become pregnant, but did because of Clomid. Then, due to poor uterine lining, the woman miscarries. If the man in question has not been tested, it may not have anything to do with the woman, but poor sperm quality. No one knows for sure what causes the higher rate of miscarriage, but there are several factors to consider, not only Clomid. Jess, I payed out of pocket for my first month of generic Clomid. I got it at Wal-Mart for $25, 5 pills. The brand name was about $75, if I remember correctly. Good luck to all, lots of baby dust.


D. - August 9

But the original question was is there a high risk of m/c over a "normal pregnancy". My origianl response not HIGH, just HIGHER. Granted there may be even more issues to consider, and for women with those issues, their chances may be even greater than a woman who does not have issues at miscarrying. But shame on the doctor who would allow a woman to go into taking clomid without taking care of the other issues first. But there's really been no definitive answer on endometriosis and miscarriage. Some researchers say it's possible, while others say there's no correlation. In order to avoid any of the issues with Clomid, probably the best answer is Letrozole over Clomid. No lining issues, good follicular response, Here's a good read: --- Letrozole may overcome CC miscarriage risk
Source: Fertility and Sterility 2004; 82: 1561-3

Comparing the effects of the aromatase inhibitor letrozole for superovulation with those of clomiphene citrate in women undergoing intra-uterine insemination. Superovulation with the aromatase inhibitor letrozole achieves similar pregnancy rates as those obtained with clomiphene citrate (CC), and a lower incidence of miscarriage, research suggests. Although CC remains the standard ovulation-inducing agent for superovulation and intra-uterine insemination (IUI) in many fertility clinics, treatment with the drug is thought to incur a series of adverse effects, including a higher rate of miscarriage than that seen in the general population.
In view of this, Haya Al-Fozan and co-workers from McGill University in Montreal, Québec, Canada, compared the effects of 100 mg CC for superovulation with those of 7.5 mg letrozole in a randomized study of 154 women with idiopathic infertility undergoing IUI.

The total number of developing follicles following superovulation was comparable between the women taking letrozole and those given CC (5.7 vs 4.8), as was endometrial thickness (7.1 vs 8.2 mm) and the pregnancy rate (11.5 percent vs 8.9 percent). However, while all non-ectopic pregnancies (n = 11) in the letrozole group are still ongoing, four of the 11 pregnancies in the women given CC have resulted in miscarriage.

While acknowledging that the optimal dose of letrozole is yet to be determined, Al-Fozan et al conclude: "In any event, letrozole could be used as an alternative to CC."

Posted: 24 December 2004


Lena - August 9

Drew, this latest research totally negates the former article. The former article attributed clomid m/c to poor egg quality and thin linings. This study, however, indicated that women with idiopathic infertility taking clomid have similiar egg production and lining thickness as woman taking Letrozole. The purpose of this study was to prove that Letrozole could be used as an alternative to Clomid, not to show that Letrozole was superior to Clomid. This difference is very significant as it impact the organization of the study, its population groups, and the way the data is analyzed and reported. To simply say that 4 woman on Clomid m/c compared to 0 woman on Letrozole is just a report of the data, its not an analysis or conclusion that clomid causes a higher incidence of miscarriages. More information is needed to interpret the data. For example: What were the population sizes of each group? Its possible that the Clomid group was 4 or more times greater than the Letrozole group. What were the conditions of the pregnancies? Were the woman under the care of the same physician or different physicians? Were the groups in the same geographical local. Did one group contain more smokers or other health risks? Were the ages and health of the women in the two groups comparable? Any of these could make a significant difference in the data provided but necessary to draw the conclusion that clomid causes increased m/c.

The FDA collects data on all prescriptive medications and provides national statistics on drugs. The average m/c rate for woman on Clomid is 31% compared to 30% for woman on Letrozole. The national average of m/c for women taking no fertility drugs, however, is 33%. Statistically speaking these percentages show no differences.



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