Poor Response to IVF Drugs??? Need Advice!
58 Replies
trying4pg - June 30

Hi there. I am just in the middle of my first IVF cycle and am disappointed to say that I am having a poor response to the IVF drugs. I am supersuprised because I seemed to respond so well to clomid in the past. However, so far all my levels have been normal and I don't understand. Over the past 2 years, there has never even been a hint of low ovarian reserve by any of my doctors. On day 7, I only had 4 potentially usable follies and we need to make a decision on Monday to decide whether to IUI the cycle or continue. I was taking 225 of gonal f til yesterday, when they upped me to 450. Any comments or suggestions would be really appreciated.

 

kms1 - July 1

Hi trying4pg, sorry to hear of your problem with the stims. I was having a similar problem using Follistim last year and they changed my meds. I was also using nasal spray prior to the injections. . . we ended up scrapping the IVF and did IUI and I got pregnant, but miscarried around 7weeks. I have taken some time off and am just now ready to start back TTC. I never had a problem getting pregnant before I have an older daughter from a prior marriage, and couldn't believe when my day 3 labs came back with poor ovarian reserve. Have you had the testing done for FSH and Estradiol? There is also an Inhibin B test that shows the same thing. I am going to give IVF 1 try as soon as I can get in (about 5 weeks) with the RE. SO when it is all said and done - I likely won't actually get started till September or October and DH said we can try till Christmas, but it has caused such a strain on our relationship in the past - neither of us thinks we can take more than that. Good luck to you & even if you decide not to proceed with the IVF - you may still have luck with the IUI!! Baby dust to you!

 

ROBYN - July 1

Come join us on the IVF thread JUN/JULY all of us have gone thru IVF and someone should be able to answer your question.

 

leahb5 - July 1

hi trying...i can completely understand, i was in your shoes at one time. heres my story, i did fine with clomid but with the ivf meds not good. i took lupron for about 2weeks before they did my first u/s to check follies at that time i had 15total little antral follicles. so they started with bravelle(same as gonal f) 225iu once a day, went back 4days later and hardly any grew. so they kept me on those meds and 2days later went back and 5were started. not good enough though so they upped my dose to 300iu and still only looked like possible 5follies for ivf. well here's where is got tricky...my doc decided to put me on a split dose i took 225iu in am and 225iu in pm. did this for 5days, which is rare he said we would def have 5 which was fine to go ahead but he thought the day of retrieval i might have some extra ones that caught up. so expecting only 5 i was shocked to see i had 9 all mature. 7 fertilized 4 divided we put back 2 froze 1 and due on feb. 2 with another one!!! hang in there, if they are great follies that will be all you need. i went from thinking i was going to have to switch to iui to becoming pg! the 450 will work!! just believe it, i did! good luck to you and please write back and let me know how your cycle is going btw i'm only25 and still had a poor response. and remember some bodies take a little longer to respong that might be you!!

 

Christina97 - July 1

Hi there! I am in the same situation as you trying4pg. I was started out 12 days ago on only 150 of Follistim (2 nights) then 225 (2 nights) then they finally upped me to 300 and have been on it since then. Now also doing 150 of Menopur. I only have 7 follicles, they saw 10 on Wednesday, then 7 again Friday and yesterday and this morning they only saw 4. I am so confused. Had the same as you as I responded well to clomid so it could be that we just needed to start at a higher dosage and we weren't. My estrogen/estradiol levels are increasing so all looks good on the levels side for me as well. But, we are going to have to make the decision to convert to an IUI because I don't want to waste one of my 2 covered IVF attempts. I am getting a lot of encourgement from the other IVF boards that talk to quality and not so much quantity. Please keep me posted - my heart is with you because I am going through the same thing and know I wish that this cycle is successful for you! You never know!!

 

trying4pg - July 1

Thank you all so much for your stories...it really heals my heart, which is totally broken right now...the massive drugs I am taking doesn't help my mood swings either. I guess I will see where we are at tomorrow when I go for my u/s and blood work. kms...you and I are definitely in the same boat...I had an older daughter from a previous marriage too - no probelm- and now...I am going nuts now that this is so difficult. I never actually received my day 3 FSH and estradial numbers ( I will ask on Monday, but they said that they were "fine". Robyn...thanks so much for the invite...I might just take you up on that ...Leah...thanks so much for your story...I didn't understand one part...are you pregnant and due Feb 2nd...is that what you were saying? I will definitely keep you updated...thanks so much. Christina...I am so glad you responded...that sounds crazy...and how do those numbers happen. Do they hide...or do they pop...or what. Please keep me updated. I have the big IUI/IVF decision to make this week too and it is a difficult one because I have had lots of unsuccesful IUI's in the past, although none of them like this one with meds and u/s. Basically the IUI's I have had in the past I could have done myself with a turkey baster...but TMI I am sure. I went for acupuncture yesterday, which I have been doing for the last 5 weeks or so. So we increased the blood flow to my uterus significantly (I felt quite light headed afterwards...weird huh?) So, I guess I will just have to see what happens huh? Thanks again for all your comments. Baby dust to everyone!

 

Christina97 - July 2

I went to the dr. today and I do have 10-11 follicles, but only 5 that are growing and they are all over the board in size. Sorry I didn't clarify that yesterday with my post! My dr. won't do an IUI - need to only have 2-3 at the time of retrieval and he won't let me cancel. I posted on another board that they only thing I need to have hope in is with quality, but I don't feel that hopeful that I will even make it to a transfer, but I will keep you posted. I was told they might trigger me on Thursday, but it depends on how the next couple of days go...I hope you have some good news today!!! I'll check back later :)

 

trying4pg - July 2

Christina - I think that is awesome...you can't do any more than that anyways. As long as you have a few good ones...seems to be the mantra around. I think it sounds like you are having a really good cycle. Mine seems about the same right now....as of today...I have 5 that seem to be growing...with one poor little guy just lagging behind. You can never tell though. So I was really suprised when my doctor didn't even suggest IUI'ing, but discussed triggering me on Wednesday. So today is definitely better than on the weekend. Keep in touch as I really want to know what is going on with you.

 

Christina97 - July 2

That sounds good for you too! In fact, I was told the same thing about one egg that was a "wild card", LOL! Also sounds like we had the same conversation with the Dr. today...so, you and I will need to pump each other up on focussing on the qulaity of these little guys. I was told they could trigger me on Thursday so it looks like you and I are really in synch...I will let you know more as the week passes as I have dr's appts scheduled to Wednesday. Thanks for virtually holding my hand through this - last week was just awful for me, but this week is kind of better. I think I am just tryng to be realistic, you know?

 

trying4pg - July 4

Hi Christina! How are your appts. going? Let me know. I have another u/s tomorrow morning and then they will tell me whether they are going to trigger me or not....so here's hoping our little follies grow...god knows they have had enough time. I will update you tomorrow or thurs as I have to travel 3 hours each way to get to my RE.

 

Blakey - July 4

Hi Christina- hun, if you convert to an iui, vs proceeding with your IVF cycle, you should get a refund for the iVF cycle. I had a similar situation in the past..where the protocol my RE prescribed was awful, and I didn't respond at all! After like 10 days of meds, I only had 1 follicle..needless to say, I was shocked! it was the protocol! I had always responded well on clomid for my iuis,., had like 6-7 follicles, then with my 3rd IVF, I had new protocol, and had 11 follicles, I actually got pregnant, but had a missed m'c at 12 weeks. We are not giving up, and will try one more round of IVF, have been paying out of pocket, but I am still waitng for AF, and may have an obstruction...but don't give up!Sometimes the protocols our RE's prescribe are "hit or miss" and they learn from the first time round. They need to see what are bodies respond to. So Christina, if you opt to do an iui vs. your IVF cycle...they should refund you, and you cn use that money towards your next IVF cycle...that is what made me make that decision in the past. The IVF cycle that was poor, I cancelled, nd did an iui...I wanted to put ittowards a cycle that was much better. so knowing that helped me make the decion, and knowing that the money was there to do another round. It should be the case for you also...good luck!

 

Christina97 - July 5

Blakey - thanks so much for your post and I really hope you are lucky on this next cycle and get your BFP! My dr. won't do the IUI and I was told about 2 weeks ago that I wouldn't lose an attempt (one of 2 covered IVF attempts I have). apparently I have one egg above their IUI "cut-off". I hope that if I don't make it to transfer this time with my 4-5 follicles (most likely 4) that I will next time.
trying4pg - hey there! They are triggering me tonight and I have the retrieval on Friday...How about you? I have to say, Sunday through Tuesday will be hard with waiting to hear if they fertilized and survived. I am nervous for it. I left the dr's office today kind of crushed because I feel like I should be happy and I envy the women with more eggs because this step must be so exciting for them. The only good news I had today is that my follicles grew nicely - all are over 18 and my lining is at 14. That was good news because I have a luteal phase defect as well. What about you? Are we on the same schedule? What did they say at your last appt? Anxious to hear and wishing lots of postive vibes :)

 

Christina97 - July 5

I didn't check over my post - my retrieval is Saturday, not Friday as I mentioned above.

 

Blakey - July 5

Christina- thanks so much too for your good wishes...good luck with everything....that is awesome that you are continuing, and that your triggering soon.... yay for you! Get excited....and remember...it's QUALITY over quantity...your 4 follicles soundgood...As you mentioned really good sizes too, so they most likely will be mature, and hold that perfect golden egg for you! All the best..and keep posted on how things go,.Hi trying...good luck to you also. I hope you get a good report today from your RE..wow..God love ya, 3 hours to your clinic...wow! It's just gotta work for you then! :) Positive thoughts for you girls!

 

trying4pg - July 5

Hi guys - well Christina - you and I are very close...I triggered last night - hubby has been giving me the shots all along and I notice that he has been getting more and more aggressive as we go....so I am thrilled to say I have taken my last shot for a while. As of yesterday's appt, I believe I have six fairly good sized follies...but who knows...everytime I am in there they either lose one or find one...what the heck. I just want to get three good fertilized eggs out of the whole deal...so heres hoping and praying. Good luck to you Christina....I know for me I do the retrieval on Friday and they will get back to me that day to say how things went...then Sat. a.m. they will tell me if they need DH to give another sample or not...so I am expecting a call Sat a.m. from the embryologist...so maybe you can expect the same. I am feeling really bloated right now...all my eggs in one basket I guess. Blakey - thanks so much for your positive words. I really hope the next one works out for you. Do you have to have an HSG to see if there is an obstruction and if so ...when? Gotta fly for now gals...I guess I will be away for a couple of days...I think I will hotel it after surgery as they might need dh to provide second sample on sat a.m. and frankly this driving back and forth is killing me. Later and lots of baby dust....and good egg vibes!

 

trying4pg - July 5

Alright...the eggs in one basket joke was pretty bad...don't know what I was thinking!

 

Blakey - July 5

Hi guys!
Trying...that is great news that your having your ER tomorrow..whewhoo!! I am so excited for you! see, you didn't give up, and those follies continued to grow for you. Here's hoping that one (or maybe even 2) of those follies holds the perfect golden egg for you!! I m so excited for you- and Christina you'll be next! Wishing you both truckloads of baby dust wishes...

Trying, I go in tomorrow for more blood work so my RE can see where i am in my cycle. I pray I don't have an obstruction, but my body is telling me I might. @ ruptured cysts in the months of May and June, right when AF was due..just to suspicious. I guess time will tell. If I do get AF it will be next weekend, or again, I could be getting another rupture. its as my RE pointed out..she thinks I am definitely ovulating (the past 2 months since my procedure) she thinks theirs an obstruction because my lining wants to shed, but it can't something is stopping it, and that's when I get the pain, of the cyst. I am nervous but tryoing not to think about too much, and know my RE is monitoring. I guess time will tell. Yes, I am thinking that I will most likely have to have a hysterscopy to ck for scar tissue. Just praying I won't need another lap0- but will if theirs scar tissue. All of these obstacles..and Its out of my control...(big sighs) trying to remain positive. Good luck!! :o)

 

Message:


New to the forum?

Sign Up Here!


Already a member?
Please login below.





Forgot your password?
Need Help?