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MTHFR & successful pregnancy
7 posts on this thread and the last post was on November 3rd, 2010 2:25 PM by bll0217
sandilb - December 1st, 2007 7:42 PM

My post is not a question, but is an FYI for people looking for info & hope after receiving a Dx of MTHFR. I was terrified that I would suffer another loss, but the MTHFR was actually a blessing! (I am compound hetero.) I was on Lovenox thru-out my pregnancy (& 6 weeks post delivery), I also took prescription folic acid, prenatal vitamins, baby aspirin, progesterone and prednisone... too much medication, but SOOO worth it. I have a happy, healthy beautiful 5 month old. I WISH I had found more posts like this when I was diagnosed. My OB/GYN took the same meds herself (after numerous losses) & she had a beautiful girl 6 months before I delivered. Hope this gives someone hope while researching a scary diagnosis!


kelsmi - December 2nd, 2007 8:10 AM

Just curious...what IS "MTHFR?"


girlt73 - January 2nd, 2008 9:02 PM

I totally agree with you. When I was diagnosed in 2004 there wasn't a thing out there about MTHFR. I am trying to conceive again and was doing some surfing on the net ans can't believe all of the info out there! Thanks everyone for sharing your experiences, it helps to know you are not the only one!


jennifer taxson - January 9th, 2008 4:28 PM

i am also compound hetero WITHOUT elevated homocystein levels. my RE + peri have prescribed lovenox until week 14 of my pregnancy. (i should add that they reluctantly did so and are most confident the Rx folic acid would do the trick, (in addition to progesterone, prenatal vi and a baby aspirin.) any thoughts on why my treatment would be 14 wks vs the entire pregnancy?


kellyannrenee - February 21st, 2008 10:36 PM

My post is not a answer. I have a 6 year old daughter and had 3 miscarriages due to MTHFR. My ob/gyn told me after the third miscarriage it was normal. I had to push my gyno to test me. I was diagnosed with MTHFR 3 years ago.

I found out a few days ago I am pregnant. I am so happy, but so scared of another miscarriage. I started to take prenatal vitamins, extra folic acid and baby aspirin. My question for the ladies that are taking other meds than the ones I listed. What is the reason for the other meds such as progesterone and prednisone during pregnancy?


kellyannrenee - February 21st, 2008 10:38 PM

MTHFR is Methylenetetrahydrofolate reductase (MTHFR) is a rare genetic defect that can lead to complications in pregnancy . I copied this for others that dont know what MTHFR is and can cause miscarriages.


Christy - February 22nd, 2008 10:10 AM

I got a dx of MTHFR when I was pregnant with my son. I honestly don't know to what extent I have it, but it is a milder case, if that is putting it correctly. I took baby aspirin and folic acid throughout the pregnancy and everything went fine. He is a healthy 27 month-old now. Incidentally, I was on BCP for 13 years prior to that with no problems or issues as well. I'm currently ttc for #2 but nothing has happened for 13 months. The doctor said the MTHFR has nothing to do with my current fertility issues since I haven't even been able to get pregnant yet. Anyway, my story isn't quite so exciting, but there you have it. GL to you all!


bll0217 - November 3rd, 2010 2:25 PM

Hello, my husband and I have just experienced our 3rd miscarriage (all first trimester) - all just over a year's time. After the 2nd miscarriage, my OBGYN ordered a round of blood tests - and in the meantime I was to take baby aspirin up until the next time we became pregnant. The results from the labs indicated that I was/am positive for the MTHFR genetic mutation (a compound hetero). Extra blood tests were ordered from an outside hemotologist and no other abnormalities showed. With this knowledge in hand, my OBGYN said as soon as we become pregnant the next time, to come in and begin Lovenox injections immediately (blood thinner). No mention of extra folic acid, B vitamins or any other supplements were brought up. Overall, I was on baby aspirin and prenatals up until the time of pregnancy; then switched to daily Lovenox injections (40 mg), prenatal vitamins (with iron), prometrium (progesterone hormonal supplements) and a DHA supplement. As mentioned before, the baby aspirin stopped as soon we found out we were pregnant with this time around.

Now that we have experienced our third loss, I am angry and feeling quite alone in this battle to find reasons and causes. Why can't I hold onto these babies?

Has anyone been in a similar boat? Can you please shed any light on this subject for me? What route did you take - any other medications, vitamins, that you took prior to and during your pregnancies, etc? Any other actions/steps we need to look into?

We just had an initial consultation with a fertility specialist. This Friday I will have bloodwork drawn, thyroid checked and uterine study (HSG) this December after I have been through my regular cycle. Next week I will be meeting with a hemotolgist (blood disorder specialist).

What am I missing? I feel like there ARE answers but that the medical field is not quick to say that MTHFR is a strong cause for recurrent miscarriages. I am utterly lost, confused and desperate to find answers.


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